you gals will have fun!!
food downtown:
The Strip Club - steakhouse where you can cook your own meat - really neat and not too pricey
Quarter Kitchen - pricier but good food
Grab & Go Subs - good sandwiches
Extraordinary Deserts - amazing deserts and I mean AMAZING!! Go to the Hillcrest location, I like it better
going out/clubs/bars:
The Ivy (hotel) - they have a nice rooftop bar and a pretty popular club downstairs
Whiskey Girl - fun dancing spot (usually only on the weekends though)
Hard Rock Hotel - they have a fun club downstairs - can't remember the name
The Shout House - dualing piano bar - this place is a lot of fun!
Fumari - low key hookah bar if you like that kind of thing
Anyway - if you let me know specifics of what you are looking for I can definitely lead you in the right direction as I was born and raised in SD. What hotel are you staying at?