My opinion is it's your wedding do what you want!
If you had your wedding back home you would most likely have a head table with your MOH and Best Man therefore the Wife would be sitting elsewhere.
The other option is do one long rectangular table and you guys sit in the middle and have the MOH and Best man sit on either side of you and the wife sit next to her husband.....
This is what we did for our wedding - one long table. We had a wedding party of 5, and I had the Maid of Honor and Best Man set next to my husband and I and then their partners beside them. I had each member of the wedding party sit beside their significant other. I also had our parents sit directly across form us, with our dads seated beside each other. It worked out perfectly, no one felt left out or separated.